Sure.
I have seven accounts myself (only four active). I'm not sure how many we are allowed.
I sell quite different items on each ID.
Some have posting IDs, some a buying ID and a selling ID.
Some have forgotten the password for a little used ID and had to open another.
Some new sellers end up poisoning an ID while they learn how to navigate online selling and abandon that for a fresh account
If you look for a particular ID in Advanced Search you are sometimes given a number of similar names, because none of us is as imaginative as we think we are.